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KMID : 0360419780140010013
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Korean Journal of Pharmacology
1978 Volume.14 No. 1 p.13 ~ p.23
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Studies on the Changes in Heart Rate and Blood Pressure Induced by Central Norepinephrine and Clonidine
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Abstract
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1) It was attempted to clarify the sites of action of central (either intraventricular or intracisternal) norepinephrine(NE) and clonidine to cause cardiac slowing and hypotension in urethane-anesthetized rabbits.
2) NE produced cardiac slowing but indistinct effect on blood pressure. Clonidine produced cardiac slowing and hypotension.
3) Intraventricular and intracisternal administration of NE, clonidine, phenylephrine and isoproterenol did not make difference in their effects, except that the onset of cardiac slowing by intracisternal NE was more rapid than intraventricular NE.
4) Upon repeated administration of NE at the intervals of about two hours, blood pressure responses changed to the pressor ones, the cardiac slowing unchanged. By this procedure the cardiac slowing as well as the hypotension by clonidine were gradually diminished.
5) Clonidine, when given during the NE effects were persisting, did not produce the lowering of blood pressure and further decrease of heart rate. NE, when given during the clonidine effects were persisting, produced marked elevation of blood pressure but did not produce further decrease of heart rate.
6) After intraventricular administration of regitine or desmethylimipramine, the cardiac slowing effect of NE and the clonidine effects were not observed, whereas NE produced marked elevation of blood pressure.
7) Reserpinized rabbits showed pressor and cardiac accelerating responses to NE; slight pressor and little cardiac responses to clonidine.
8) It seems that the cardiac slowing by both clonidine and NE as well as the hypotension by clonidine are mediated by the presynaptic α-adrenoceptors in the brain but the pressor responses to NE and clonidine are mediated by other site(s) than the presynaptic ones.
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